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Hepatotonic
 
  • Livron
  • Toxiliv
Livron DOWNLOAD BROCHURE
Herbal Hepatotonic

Composition:
Tephrosia purpurea 40%
Eclipta alba 20%
Andrographis paniculata 10%
Terminalia chebula 10%
Ocimum santum 10%
Excipients Q.S.

Salient features
  • Livron increases the functional activity of Liver to detoxify and counteract damage caused by aflatoxins.
  • Livron reduces fibrosis and stimulates new hepatocyte formation.
  • Livron protects liver from harmful toxins and helps in controlling fatty liver syndromes.
  • Livron inhibits the activity of Clostridium & E.coli.

Added advantages
  • Livron prevents bronchitis, diarrhea & acts as an intestinal tonic.
  • Livron is useful growth oromoter, antibacterial & appetizer.
  • Livron acts as an immunostimulant & antioxidant.
  • Livron improves the quality of meat by reducing its cholesterol level.
  • Livron also posseses anti-inflammatory, antipyretic & antifungal activity.
  • Livron increases the neutrophil & lymphocyte count with enhanced phagocytic activity.

Livron

Tephrosia purpurea
Part used – whole plant
Advantages It is alterative, cures diseases of liver, spleen, heart, blood. According to unani system of medicine, root is diuretic, allays thirst, enriches blood, cures diarrhea, useful in bronchitis, asthma, liver spleen diseases, inflammations, and boils. Leaves are tonic to intestines and a appetizer. According to Ayurveda, plant is digestible, anthelmintic and antipyretic.
   
Eclipta alba
Part used – whole plant.
Advantages It has antihepatotoxic activity. It gives symptomatic relief in epigastric pain, nausea and vomiting . The leaf extract is powerful liver tonic and rejuvenative. It has a profound antihepatotoxic activity. A cardiodepressant activity was also observed in it when used for hepatic congestion. It is used as remedy for the treatment of bleeding, haemoptysis, haematuria and itching, hepatitis, diphtheria and diarrhea. It is a cooling and restorative herb, which supports the mind, nerves, live and eyes. Plant has traditional external uses like in eczema and dermatitis.
   
Andrographis paniculata
Parts used – leaves and stems.
Advantages It possesses antihepatotoxic, antibiotic, antimalarial, antihepatic, anti thrombogenic anti-inflammatory and antipyretic properties. It is also used as an immunostimulant agent. The plant extract exhibits antityphoid and antifungal activities. The plant extract increases the cytotoxic activity of lymphocytes against cancer cells, hence has a potential for being developed as a cancer therapeutic agent.
   
Terminalia chebula
Part used – mature fruits.
Advantages It is a laxative, nutritive and appetizing. It is a antiflatulent and used in abdominal colic. It is effective in skin diseases, pruritus and heart diseases. It is a brain tonic, promotes vision and a rejuvenative tonic. It is used as expectorant. It is used in urinary disorders, intermittent fever, abdominal tumours and as alterative.
   
Ocimum sanctum – commonly known as Tulsi
Part used – whole plant.
Advantages It has antioxidant properties. It is used in Ayurvedic remedies for common colds, stomach disorders, inflammation ,heart disease, various forms of poisoning and malaria. Recent studies suggest that Tulsi may be a COX-2 inhibitor, like many modern painkillers. It is also effective in diabetes by reducing blood glucose levels. Studies showed that it reduces the total cholesterol levels. Tulsi has beneficial effect on blood glucose level due to its antioxidant properties.
   
Drug action
Alterative, antihepatotoxic, rejuvenative, immunostimulant antioxidant, anti-inflammatory and antipyretic

Indications
  • As a liver tonic.
  • To improve liver functions in hepatic disorders.
  • To improve feed conversion ratio (FCR).
  • As a growth promoter in broiler and layer

Administration & dosages:
To be given orally.
Cattle and Buffaloes 5-10 g.once daily for 10 days.
Sheep and Goat 3-5 g. once daily for 10 days.
Broilers / layers 100 g. in 100 kilogram feed concentrate regularly
Repeat the dose if required or as directed by the veterinarian.

Presentation
100 g., 1 kg and 10 kg.
Toxiliv DOWNLOAD BROCHURE
Hepatotonic

Compositon
Each 10 ml contains
Choline chloride 2000mg
Protein Hydrolysate 50mg
Yeast Extract 40mg
Inositol 35mg
Niacin 24mg
DL Panthenol 2.5mg
Vitamin B12 3.3 mcg
(equivalent to vitamin B12 available from 0.55 ml of liver extract 1:30)

Salient Features
  • Toxilive is a feed supplement to boost liver functions.
  • Toxilive contains choline chloride,yeast extract, niacin, DL panthenol and inositol.
  • Choline is required for the synthesis of neurotransmitter acetylcholine.
  • Prevents pathological changes and the accumulation of of fat in liver and kidneys.
  • It facilitates lipoprotein synthesis by liver and prevents lipidosis.
  • Improves physique and growth rate of live stock and poultry.
  • Helps in normal carbohydrate metabolism.
  • It helps to increase peristalsis in atony and paralysis of the lower intestine and to help relieve gas retention and abdominal distension.
  • Toxilive as supportive therapy in liver dysfunctions due to hepatic diseases, parasitic diseases, aflotoxins, drugs etc.
  • Toxilive improves feed intake, carbohydrate metabolism and milk fat percentage.
  • Toxilive improve growth and livability in livestock and poultry.
  • Toxilive as supportive therapy in diarrhea and constipation due to hepatic disease.

Toxiliv

Action of individual ingredient

Choline chloride
Choline is one kind of vitamin It is the main element of lecithin. It is of great importance for the growth, breeding and nutrition of fowls and livestock. Because young fowls and livestock lack the function of synthesizing choline by themselves, the required choline is all from feed supply. Though choline exists widely in most natural foods, the choline content can not meet the demand for animals’ growth. Thus, it is necessary to add choline in the feed to ensure their rapid and healthy growth.

Choline chloride can help to improve the physiological function of the resynthesis and transformation of amino acid. It has functions of preventing pathological changes and the accumulation of fat in livers and kidneys. Thus it can improve the physique, premonition and growth rate of fowls and livestock, it can also improve the survival rate of newborn pigs, as well the growth and survival rate of fishes.

Choline is essential as a component of lecithin, a key phospholipids for maintaining cell membrane structure and function. It plays an important role in lipid metabolism, facilitating lipoprotein synthesis by the liver and preventing hepatic lipidosis. Choline is required for the synthesis of the neurotransmitter acetylcholine

Signs attributed to choline deficiency in ruminants are restricted to those with heavy growth or lactational demands. Feed intake and milk fat percentage were increased following choline supplementation in lactating cows. Choline deficiency in pigs is characterized by reduced growth rate, poor conformation, incoordination, joint rigidity, reproductive problems and hepatic lipidosis. Choline deficiency in puppies and kittens has been characterized by decreased growth and hepatic lipidosis. Choline deficiency in poultry causes growth retardation, perosis, fatty liver and decreased egg production.

Protein Hydrolysate
Protein Hydrolysate consists of amino acids and short chain peptides, which represent the approximate nutritive value equivalent to suitable protein from which it has been derived by enzymatic hydrolysis. It provides a better source of easily assailable mixture of amino acids in a concentrated form.

In the Soviet Union protein hydrolysates are used for the treatment of hypoproteinaemia, exhaustion and intoxications, particularly in young farm animals (e.g. calf diarrhoea, white muscle disease).

Yeast
Yeasts are unicellular, although some species with yeast forms may become multicellular through the formation of a string of connected budding cells known as pseudohyphae, or false hyphae as seen in most molds. The yeast species Saccharomyces cerevisiae has been used in baking and fermenting alcoholic beverages for thousands of years. The term "yeast" is often taken as a synonym for S. cerevisiae.

Yeast is used in nutritional supplements, where it is often referred to as "nutritional yeast". It is a deactivated yeast, usually Saccharomyces cerevisiae. It is an excellent source of protein and vitamins, especially the B-complex vitamins, whose functions are related to metabolism as well as other minerals and cofactors required for growth.

Inositol
Inositol, an isomer of glucose, has traditionally been considered to be a vitamin B substance although it has an uncertain status as a vitamin. Sources of inositol include whole – grain cereals, fruits and plants, in which it occurs as the hexaphosphate, phytic acid.

Inositol appears to be involved physiologically in lipid metaboloism and has been tried, with little evidence of efficacy, in disorders associated with fat transport and metabolism.

Niacin
Niacin or its active form nicotinamide, is a metabolic essential for all animals but is a dietary essential only under special conditions. Dog may experience niacin deficiency if fed improperly.
Niacin is converted in the body to two similar coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), that are integral to hydrogen transfer in all major metabolic pathways. Although they are structurally similar, they serve different functions. NAD is more closely associated with transfer of hydrogens to oxygen in oxidative metabolism. NADP is more commonly associated with hydrogen transfer in synthetic reactions in the body, particularly reductive steps in lipid synthesis.

Nicotinic acid is reported to have a favorable effect on blood lipid profiles, raising high density lipoprotein (HDL)- cholesterol and lowering low – density lipoprotein (LDL)- cholesterol..

Black tongue in dogs is the classic disease associated with niacin deficiency. In most species, oral lesions affecting the mucosa give a blackened appearance and result in a thick saliva, malodorous breath , and ulcerative lesions. Diarrhea and anemia also are common as well as the usual signs of vitamin deficiency such as in appetence and poor growth. Corn and cereal grains contain fairly adequate quantities of niacin, but the vitamin is in a bound and unavailable form. Swine and poultry on intensive production with high concentrate cereal grains or corn should receive supplemental niacin or nicotinamide.

Ruminants do not require an exogenous source of either niacin, nor do horses ( Robinson and Slade 1974). Dogs develop the classic animal deficiency syndrome. Swine and poultry often require additional niacin. The specific requirements vary with type of production and amount of precursor available.

Niacinamide: proven benefits
  • Maintains normal function of skin, nerves, digestive system.
  • Corrects niacin deficiency.
  • Dilates blood vessels.
  • Control ketosis, stimulate rumen protozoa.

What this vitamin does:
  • Aids in release of energy from foods.
  • Helps synthesis of DNA.
  • Becomes a component of two co-enzymes (NAD and NADP), which are necessary for utilization of fats, tissue respiration, production of sugars.

DL Panthenol
DL-Panthenol is a stable lit racemic mixture of D-Panthenol and L-Panthenol. The human body converts D-Panthenol to Pantothenic Acid (Vitamin B5), a natural constituent of healthy hair and a substance present in all living cells. Only D-Panthenol is converted to Vitamin B5 and not the L-Panthenol. So the racemic D,L-Panthenol has only half of the physiological activity of D-Panthenol.

Metabolic functions Pantothenic acid functions mainly as CoA, which facilitates reactions of carboxylic acids catalyzed by such enzymes as pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, fatty acid synthetase, propionyl CoA carboxylase, and acyl CoA synthetase (Mc Dowell 1989e). It is necessary for the activation of acetic acid, as aceyl CoA for entry of carbon skeletons into the TCA cycle, synthesis of fatty acids and cholesterol, and the production of the neurotransmitter acetylcholine. As acyl carrier protein, it functions as a carrier for intermediate- chain acyl groups in the synthesis of fatty acids (Mc Dowell 1989e)

Signs of deficiency
Pentothenic acid deficiency in animals is characterized predominantly by disorders related to its prominent role in intermediary metabolism. Pantothenic acid deficiency is uncommon in adult ruminants and horses, whose needs are provided by ruminal and large- intestinal microorganisms, respectively. ( Cunha 1991e).
Clinical signs of deficiency in growing calves have been produced experimentally, including anorexia, poor growth, diarrhea, rough hair coat, and particularly a scaly dermatitis around the eyes and muzzle. Many practical swine diets, particularly those based on corn or soybean meal, contain marginal level of pantothenic acid. Deficiency in pigs is characterized by anorexia, poor growth, hemorrhagic diarrhea, dermatitis, and locomotor disorders, particularly affecting the hind limbs (Mc Dowell 1989e). the hind limbs progressively show tremors, spasticity, and an axaggerated gait ( goose stepping), due to demyelinization of nerves in the dorsal root ganglia (Blair and Newsome 1985). Pantothenate deficiency causes inappetence, weight loss or growth depression, lowered antibody responses, and hind limb spasticity in dogs, and hepatic lipidosis in kittens (NRC 1985,1986; McDowell 1989e). Pantothenic acid deficiency in poultry produces dermatitis, hperkeratosis, broken feathers, and decreased growth rates as well as reduced egg production and hatchability (McDowell 1989e).

Dietary requirement, indications and use
Intrinsic factors
Breed and strains differences in pantothenic acid requirements have been documented in pigs, resulting in the need for up to 50% increases in supplementation ( McDowell 1989e). In adult ruminants and horses, pantothenic acid synthesis by gastrointestinal microflora is adequate under resting conditions, but as is the case for other species, requirements increase with stress, growth, gestation, or lactation, thereby necessitating supplementation. The urinary excretion of pantorhenate may increase in polyuric renal deseases, there`by increasing the dietary requirement.

Extrinsic factors
Dietary fat and protein intake can affect pantothenic acid requirements, as can ascorbic acis, biotin, and vitamin B12 levels ( Mc Dowell 1989e). Increased fat intake necessitates greater pantothenate for CoA synthesis and lipid metabolism, while high dietary protein apparently has a sparing effect on pantothenate requirements. Vitamin B12 deficiency increases pantothenate requirements, perhaps by trapping more as CoA – conjugated intermediates in the aberrant metabolism of propionic acid. Stress and other dietary factors increase patothenic acid requirements as well. Gastrointestinal diseases may impair enteric flora pantothenate synthesis and subsequent absorption. Oral antibiotics also increases its dietary requirement, by inhibiting normal enteric microflora production.

Vitamin B12 (cyanocobalamin)
Vitamin B 12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production. Cyanocobalamin ( Vit. B 12) is a cobalt –containing vitamin required by cells throughout the body for conversion of ribose nucleotides into deoxyribose nucleotides, a mojor step in the formation of deoxyribonucleic acid (DNA). Thus it is an essential nutrient for nuclear maturation and cell division and deficiency of this vitamin results in generalized depression of cellular development and tissue growth.

Because the erythropoietic centres of the bone marrow are among the most rapidly growing and proliferating tissues, inadequate amounts of cyanocobalamin are sepecially manifested by decreases in erythrocyte production.

Requirement
Adult ruminants are not dependent on a dietary source of this vtamin because ruminal microflora synthesize all the required supplies of cyanocobalamin. How ever dietary source of cobalt is required by ruminal organism to synthesize vit B12 and cobalt shortage can result in an indirect deficiency of vitamin. Enteric bacteria of many non-ruminants spp. can also synthesize cyanocobalamin, thereby reducing the need for dietary source. How ever vitamin B12 deficiency may still result from inadequate absorption of the vitamin from the digestive tract. In adult ruminants and horses vit B12 synthesis by gastrointestinal flora is adequate under resting conditions but as is the case for other spp. requirement increases with stress, growth, gestation or lactation, thereby necessitating supplementation. The more rapid the rate of growth or the greater the level of production, the greater the need for vit B12. The urinary excretion of vit B12 may increase in polyuric renal diseases, thereby increasing the dietary requirement.
Gastrointestinal diseases may impair enteric microbial vit. B12 synthesis and subsequent absorption. Oral antibiotics may also increase its dietary requirement by inhibiting normal enteric microfloral production.

Absorption and storage
Vit B12 is absorbed almost exclusively in the ileum, in a carrier- mediated process with a specific receptor protein located on the microvillus border of the enterocytes. Following its transport from the enterocytes to the portal blood, vit B 12 is bound to protein called transcobalamins, which are synthesized by the liver and facilitate transport and storage of the vitamin. Liver contains much of the body stores and half life has been reported to be as long as one month .

Indications
  • As supportive therapy in hepatic dysfunction due to hepatic disease. aflotoxins, microtoxins, drugs etc.
  • Lipidosis
  • Liver dysfunction due to parasitic diseases.
  • Diarrhea or constipation due to hepatic disease.
  • To improve egg production, hatchability and weight gain.
  • To improve feed intake and milk fat percentage.
  • To improve growth and livability in livestock and poultry.

Dosage

Calf, Sheep and Dog: 3-5 ml daily for 7-10 days
Cattle, Horse and Camel 20 ml daily for 7-10 days.
Poultry  
Chicks 0.5 ml per litre of drinking water
Growers and Broiler 0.5 ml per litre of drinking water
Layers and Breeders 1.0 ml per litre of drinking water.

Presentation
1 lt. and 5 lt.