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Anticoccidial
 
  • Coccinal Plus
Coccinal Plus (Powder) DOWNLOAD BROCHURE
B.P. Vet. formulation of four proven anticoccidal agents.

Compositon
Amprolium HCl I.P. Vet. 20% w/w
Sulphaquinoxaline I.P. Vet. 12% w/w
Ethopabate I.P. Vet. 1% w/w
Pyrimethamine I.P. 1% w/w

Amprollium
Amprolium is structurally related to vitamin thiamine (B1) and is competitive antagonist, because rapidly dividing coccidia have relatively high requirement for thiamine. Amprolium acts on the first- generation schizont to prevent merozite production and has some activity against sexual stages and the sporulating oocyst. Amprolium is used for prevention of coccidiosis in chicken.

Sulphaquinoxaline
Sulphaquinoxaline is the sulfonamide. The structure of sulfonamides is similar to para- aminobezoic acid (PABA), which is required by bacteria in the synthesis of folate (folic acid). Sulfonamide interfere in the early phases of folate synthesis. Sulfonamides are used in combination with dihydrofolate reductase / thymidylate synthase inhibitors (Pyrimethamine) because of the observed synergistic effects due to activity at two places in folate biosynthesis.

Ethopabate
It is a folic acid antagonist, that improves the coccidiostatic effect of amprolium. As amprolium has poor activity against some Eimeria spp., its spectrum has been extended by using it with ethopabate.

COCCINAL PLUS
Pyrimethamine
Pyrimethamine is dihydrofolate reductase / thymidylate synthase inhibitor. Pyrimethamine used in combination with sulfonamide (sulphaqunoxaline) acts synergistically due to inhibitory activity at two places in folate biosynthesis.

Indication
Coccidiosis in poultry.

Administration and dosage
Poultry
Treatment 30 g powder to be dissolved in 50 liters of drinking water daily for 5-7 days.
Prevention 30 g powder to be dissolved in 100 liters of drinking water for 10-15 days.

Instructions
Use the medicated water as the only source of drinking water.

Presentation
30 g pouch.

Notes
Amprolium is structurally related to vitamin thiamine. Amprolium is freely soluble in water.Amprol actson the first- generation schizont to prevent merozite production and has some activity against sexual stages and the sporulating oocyst.Amprolium is used for prevention of coccidiosis in chicken. ( Adam p-1000)

Sulphaquinoxaline is the sulfonamide. The structure of sulfonamides is similar to para- aminobezoic acid (PABA), which is required by bacteria in the synthesis of folate (folic acid). Sulfonamide interfere in the early phases of folate synthesis. Mammalian and avian cells use preformed folate and are therefore not affected by the sulfonamide treatments.
Sulphaquinoxaline is used for the treatment or prevention of coccidian and coccidian like parasites (Adam p-1005)

Pyrimethamine
Pyrimethamine is dihydrofolate reductase / thymidylate synthase inhibitor. In protozoa the dihydrofolate reductase and thymidylate synthase enzymes do not exists as separate molecular entities, but instead these enzymes are part of a bifunctional DHFR / TS complex that has both DHFR and TS activity. Pyrimethamine used in combination with sulfonamide ( sulphaqunoxaline) acts synergistically due to inhibitory activity at two places in folate biosynthesis. (Adam 1005)