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Antihistamines
 
  • Lorfen
Lorfen DOWNLOAD BROCHURE
First choice in allergic disorders

Composition
Each ml contains
Chlorpheniramine maleate I.P. 10 mg.

Chlorphenamine maleate (CPM), is a first-generation alkylamine antihistamine an H-1 histamine receptor antagonist. Chlorpheniramine has been antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorpheniramine is one of the most commonly-used antihistamines in small-animal veterinary practice.

Pharmacology
In allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritus, vasodilation, hypotension, flushing, headache, tachycardia, bronchoconstriction, increase in vascular permeability, potentiation of pain, and more.
While H1-antihistamines help against these effects, they work only if given before contact with the allergen. In severe allergies, such as anaphylaxis these effects may be so severe as to be life-threatening.

Pharmacokinetics
Chlorpheniramine is well distributed after IV injection, the highest distribution of the drug (in rabbits) occurs in the lungs, heart, kidneys, brain, small intestine and spleen. It is unknown if chlorpheniramine is excreted into the milk.


Lorfen
Chlorpheniramine is metabolized in the liver and practically all the drug (as metabolites and unchanged drug) is excreted in the urine. In human patients with normal renal and hepatic function, the terminal serum half-life of the drug ranges from 13.2-43 hours.

Drug Interactions
Increased sedation can occur if chlorpheniramine is combined with other CNS depressant drugs. Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.

Indications
Allergic disorders like urticaria, dermatitis, rhinitis, mastitis, burns, drug reactions, allergic conjunctivitis, anaphylactic shiock, insect bites, stomatitis and ruminal atony in cattle.

Administration and dosage
Cattle and Horse 15-20 ml IM
Sheep, Goat, Pig and Dog 2-3 ml IM

Presentation
30ml & 100 ml