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Hormones
 
  • Hyprogen
  • Hyprogen Plus
Hyprogen DOWNLOAD BROCHURE
Saviour of life in the womb

Composition
Each ml contains:
17, alfa-Hydroxyprogesterone caproate I.P. 250mg

Description
Hydroxyprogesterone caproate is a synthetic derivative of progesterone with the pharmacologic actions of all Progestins. 17α-hydroxyprogesterone (17-P) has minimal progestational activity; however, the esterified form, Hydroxyprogesterone caproate has significant progesterone effects and a prolonged duration of action, from 7 to 14 days. 17α-Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid).

Progesterone: A hormone secreted primarily from corpus luteum of ovary. It exerts a feedback inhibitory effect on GnRh and gonadotropin secretion and thus suppresses ovulation. It is therefore used as a estrus suppression and in progesterone deficiency. Progesterone quietens the uterus and prepares it for nidation and pregnancy, promotes secretion of uterine milk from endometrial glands, causes proliferation of mammary gland acini.

Mechanism of action
Hydroxyprogesterone caproate has prolonged uterotrophic effect; it stimulates luteal actions, causes changes in uterus and vagina as seen in early pregnancy. Contractile response of the myometrium to oxytocin is inhibited. The drug stimulates a proliferative endometrium into secretion as well as stimulates the growth of mammary alveolar tissues.

Hyprogen
Indications
The injection is prescribed in the following cases:
  • Habitual abortion
  • Threatened abortion
  • Vaginal / uterine prolapse
  • Post partum anoestrus

Contraindications
Physical examination is advised prior to starting therapy.
Hyprogen injections are contraindicated in cases of undiagnosed vaginal bleeding, pregnancy or in cases of markedly impaired liver function.

Safety
The drug has antineoplastic activity.

Adverse Effects
Reported adverse drug effects with the use of Hydroxyprogesterone caproate are:
  • GastroIntestinal disturbances.
  • Oedema.
  • Allergic skin rashes, urticaria
  • Pain at site of injection.

Administration : IM

Dosage

Habitual abortion : 3ml of Hyprogen after 45 days of pregnancy repeat at every 10 days for 4-5 times.
Repeat Breeding : 2-3 ml of Hyprogen per week for 3 weeks
Vaginal/Uterine prolapse : 3ml of Hyprogen per day for 2 days
Post partum anoestrus : 3ml of Hyprogen, if no response repeat after 10 days

Presentation : 3ml
Hyprogen Plus Inj. DOWNLOAD BROCHURE
Natural Pregnancy Hormone

Composition
Each 3ml contains:
Progesterone I.P. 250mg
Benzyl Alcohol I.P. 2% v/v
Archis Oil I.P. q.s.

Progesterone is a naturally occurring steroid hormone. In Veterinary Medicine, progesterone is used in cows and mares for therapeutically (disorders of the reproductive system) and zootechnical (oestrus synchronization and preparation of donor and receptor animals in the case of ambryo transfer) purposes.

Progesterone is a hormone with different actions dependent on the period in the estrous cycle. (oestrus cycle- over a period of time many changes takes place in the reproductive system. These changes in unbred normal female repeat at fixed days of interval. This regular repletion is called oestrus cycle.) Progesterone regulates maturation of the oocytes, ovulation, myometrial quiescence, mammary gland growth and endometrial enzymes. Further more. Progesterone exerts other wide ranged effects, e.g. on metabolism, respiratory system & central nervous system.

Salient Features:
  • Inj. Progesterone (Inj. Hyprogen Plus) is official in Indian Pharmacopia Veterinary Section.
  • Inj. Hyprogen Plus, contains natural Progesterone derived from corpus luteum and placenta.
  • Natural Progesterone (Inj. Hyprogen Plus) is well tolerated by the animals.

Hyprogen Plus Inj.
  • No congenital disorders are found after treatment with natural Progesterone (Inj. Hyprogen Plus).
  • On parentral administration the plasma Progesterone concentration is elevated within the first few hours, but never higher then the values observed under normal physiological conditions.
  • In addition to its Progestational activity, it also stimulate the growth of mammary alveoli.
  • Natural progesterone is rapidly absorbed from the site of IM injection.
  • It is a endogenous hormone, thus a natural constituent of food of animal origin (dairy products and tissue/organs).
  • Supplementation of endogenous Progesterone in pregnancies potentially compromised by insufficient luteal function. (corpus luteum grows from the granulosa cells of ruptured follicles under the influence of leutinising hormone “LH” from anterior pituitary. This corpus luteum secretes hormone progesterone. Progesterone makes the uterus ready to accept a fertilized egg and keeps the cow from coming to heat. Under the influence of progesterone, the uterus produces a nourishing substance for the embryo to grow on. At the same time, a thick plug forms in the cervix, preventing any bacteria or viruses from entering the uterus. Progesterone also blocks the release of follicle stimulating hormone from the pituitary gland.)

The terms progestin, Progestagen and Progestogen are used interchangeably to refer to any of the synthetic steroids with progestational activity or that mimic the effect of Progesterone.
All synthetic progesterone differ in their pharmaceutical profile & their capacity to produce side effects in different animals species.

Advantages of Natural Progesterone over synthetic
  • May avoid incidence of uterine pathology i.e. cystic endometrial hyperplacia (Cystic endometrial hyperplasia, “CEH” is a progressive and pathological endometrial expansion caused by an increase in the size and number of endometrial glands. Endometrial glands may actively secrete fluid into the uterine lumen and CEH can eventually lead to mucometra, hydrometra, or pyometra).
  • Natural progesterone being of animal origin is compatible and well tolerated by animals. 3. No increase in G.H (growth hormone)., no development of mammary nodules hence no mammary tumors.
  • By using natural Progesterone you can avoid enlargement of soft tissue of head & neck, overgrowth of skin, elongation of bones, hepatomegaly (Hepatomegaly is the condition of having an enlarged liver) and insulin resistance.
  • No adrenocortical suppression.
  • It will not delay the onset of parturition
  • There will not be any behavioral modification, or any effect on appetite, weight or libido.
  • The dose of natural progesterone is one third to that of synthetic Hydoxyprogesterone caproate.

Indications
  • To correct failure in foetal nidation (implantation ) by administration after ovulation.
  • In habitual & threatened abortions.
  • In treatment of nymphomania (an excessive sexual desire in a female) associated with ovarian cysts.
  • For the development of udder
  • Synchronization of estrous cycles and to organize and regulate oestrus cycle. (on progesterone administeration and its withdrawal, it mimics the natural decline in progesterone and thus helps to induce the normal increase in LH and FSH required for ovulation and results in a competent corpus luteum CL.
  • Disfunctional uterine bleeding.
  • Uterine fibroma, (A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor.) & neoplasms (Cancer) of udder & endometrium
  • (inner lining of uterus ).
  • To delay estrus & Ovulation in Cattle, Swine & Dogs

Contraindications
It should not be given in incomplete abortions / retained placenta.

Dosage
Habitual abortion: 3ml Hyprogen Plus after 45 days of pregnancy.
Repeat 4-5 doses after 10 days interval in between.
Repeat Breeding: 3 ml Hyprogen Plus per week for 3 weeks
Vaginal/Uterine Prolapse: 3ml Hyprogen Plus per day for 2 days
Post Partum anoestrus: 3ml Hyprogen Plus if no response repeat after 10 days

Presentation : 3ml ampoule individually packed in catcher and boxed along with sterilized syringe & needle

*Inj. Hyprogen Plus may be used only on the recommendation & directions of a veterinarian.

Note:
Myometrial quiescence
The length of mammalian pregnancy is tightly regulated to assure the delivery of a newborn mature enough to survive the extra-uterine environment. A successful pregnancy requires near complete relaxation of the uterus for more than ninety-five percent of gestation, overcoming the inherent tendency of the myometrium to contract with stretch. This active and highly regulated process is called myometrial quiescence. It requires not only the near absence of myometrial contractions, but also its refractoriness (the insensitivity to further immediate stimulation that develops in irritable and especially nervous tissue as a result of intense or prolonged stimulation) to contractile agents.