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Anti-inflammatory & Analgesics
 
  • Feverdon
  • Feverdon Plus
  • Meloxi
  • Nimulite Plus
Feverdon DOWNLOAD BROCHURE
Herbal antipyretic and diuretic powder

Composition:
Saptaparna 3 %
Colchicum 1 %
Cincona 3 %
Giloe 4 %
Chiraita 4 %
Ajwain 4 %
Yavkshar 10 %
Madhurkshar 10 %
Julabinamak 30 %
Godanti Bhasam 4 %


Ingredients and their advantages:
Saptaparna
Botanical name: Alstonia scholaris
Part Used- Bark.
It contains three alkaloids, Ditamine, Echitamine or Ditaine, and Echitenines, and several fatty and resinous substances. The bark is used in ayurvedic as febrifuge, alterative, tonic and gastrointestinal sedative.

Colchicum
Botanical name: Colchicum Luteum
Part Used- Seed and Corm

Feverdon
Colchicum contains an alkaloid named colchicines which is 0.21 to 0.25 %. The active principle colchicines contained in the corms and seeds is beneficial in relieving pain.

Cincona
Botanical name: Cincona spp.
Part used - Bark
The bark of trees in this genus is the source of a variety of alkaloids, the most familiar of which is quinine, an anti-fever agent. It is a traditional and much utilized herbal remedy for treating all kinds of fevers.

Giloe
Botanical name: Tinospora cordifolia
Part used - Stem
It is antipyretic, alterative, diuretic, anti-inflammatory. It is used in fever, urinary disorders, dyspepsia, general debility and urinary diseases. It is also used in treatment of rheumatism and jaundice.

Chiraita
Botanical name: Swertia chirata
Part used - Whole plant.
Swertia Chirata known as Chirayata is a herb. According to Ayurveda it is a bitter tonic that has stomachic, febrifuge, anthelmintic, appetizer, laxative, alterative and antidiarrhoeic properties. Chirayatra is an effective drug for reducing fev

Godanti Bhasam

Chemical name : Calcium Sulphate hydrated
Part used - it is used in powder form
In ayurveda it is used as a antacid, astringent and febrifuge. It is a natural form of calcium that helps to maintain healthy bone structure. It is useful in fever, cough and cold.

Ajwain
Botanical name: Trachyspermum ammi
Part used- Fruit
Ajwain is much valued for its antispasmodic, stimulant, tonic and carminative properties. It is administered in flatulence, atonic dyspepsia and diarrhoea. It is a potent antimicrobial agent. It also seems to possess some anti-diuretic effect.

Yavakshara (shora)
Chemical name: Potassium Nitrate
Used as – salt.
Found native on the surface soil of the Punjab. It is alterative, febrifuge, diuretic and expectorant in action.

Madhurkshar
Chemical name: Sodium Bicarbonate
Used as – salt.
It is antacid, expectorant and diuretic in action.

Julabinamak
Chemical name: Magnesium Sulphate
Used as – salt.
It is diuretic, antipyretic and laxative in action.

Drug Action
Feverdon a combination of ayurvedic ingredients, is antipyretic, diuretic, gastrointestinal sedative and anti-inflammatory in action.

Indications
  • High fever
  • Rheumatic fever
  • Three days sickness
  • Oedematous swelling
  • Retention of urine.

Administration and doses
To be given orally in fresh water or as bolus.
Cow, Buffalo and Horses 50-75 g. twice daily for 2-3 days
Calf, Heifer, Colt and Pig 25-35 g. twice daily for 2-3 days
Sheep and Goat 15-25 g. twice daily for 2-3 days.

Presentation
150 g. and 1 kg
Feverdon Plus DOWNLOAD BROCHURE
Inflammation, pain & pyrexia always occurs simultaneously trying to treat any one of them is incomplete

Inj feverdon plus controls inflammation, alleviates pain, combats fever and restores mobility

Composition:
Each ml contains:
Paracetamol I.P. 150 mg
Mefenamic acid I.P. 50 mg

Salient features
Paracetamol
  • Preferential Cox-2 and Cox-3 inhibitor
  • Excellent antipyretic
  • Potent analgesic
  • Safe with no residual effect
  • Non Carcinogenic
  • More effective against inflammatory conditions in the C.N.S.

Mefenamic acid
  • Most powerful NSAID
  • Excellent analgesic, antipyretic & anti-rheumatic
  • High distribution at inflammatory sites
  • Decreases uterine contractions
  • Quick on set of action, peak plasma concentration in 30 minutes

Feverdon

Paracetamol
Pharmacokinetics
Paracetamol is readily absorbed with peak plasma concentration reaching in 10-60 minutes. It is distributed into most body tissue. It crosses the placenta and is present in milk. Plasma protein binding is negligible at usual therapeutic concentrations. The elimination half life is 1-3 hrs. Paracetamol is metabolised predominantly in the liver and excreted in the urine. Less than 5 % is excreted as unchanged . Paracetamol is extremely toxic to cats, and should not be given to them under any circumstances. Cats lack the necessary glucuronyl transferase enzymes to safely break paracetamol down, and minute portions of paracetamol may prove fatal.

Mode of action

Paracetamol is a analgesic and antipyretic in action. It inhibits cyclooxygenase (COX), an enzyme responsible for the production of prostaglandins. Paracetamol has no significant action on COX-1 and COX-2, which explain its lack of anti-inflammatory action and also, more importantly, its freedom from gastrointestinal side effects typical of NSAIDs. Now, recent research has shown the presence of a new, previously unknown cyclooxygenase enzyme COX-3, found in the brain and spinal cord, which is selectively inhibited by paracetamol, and is distinct from the two already known cyclooxygenase enzymes COX-1 and COX-2. It is now believed that this selective inhibition of the enzyme COX-3 in the brain and spinal cord explains the effectiveness of paracetamol in relieving pain and reducing fever without having unwanted gastrointestinal side effects.

Mefenamic acid
Pharmacokinetics
Mefenamic is rapidly absorbed and peak plasma concentration reaches in about 2-4 hrs after absorption. The plasma half life is reported to be 2-4 hrs. Mefenamic acid is extensively bound to plasma protein. Over 50 % of dose may be recovered in the urine, as unchanged drug or conjugates of mefenamic acid and its metabolites.

Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.

Mode of drug action
Mefenamic acid is a non-steroidal anti-inflammatory drug with demonstrated anti-inflammatory, analgesic and antipyretic activity in laboratory animals. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis and to compete for binding at the prostaglandin receptor site.

Indications:
  • Pyrexia of unknown origin or pain & fever associated with infections.
  • Inflammatory conditions following reproductive disorders like metritis, prolapse & mastitis.
  • Acute & Chronic inflammatory conditions like osteoarthritis, rheumatoid arthritis, myositis, lameness, pharyngitis, otitis, & rhinitis.
  • Gastrointestinal colic and renal colic
  • Mild & moderate post-operative care
  • Hip dysplasia in dog.

Contraindication
  • Paracetamol is extremely toxic to cats.
  • Hepatic, renal or cardiac diseases & peptic ulcer.
  • Hypersensitivity to drug.

Dosage & Administration deep IM injection
Large Animals : 20-30ml per day
Small Animals : 2-5ml per day
Dogs 1-2ml per day

Presentation

30ml & 100ml vial

References:
  • Recent research has shown the presence of a new, previously unknown Cyclooxygenase enzyme Cox-3, found in the brain & spinal cord, which is selectively inhibited by paracetamol, & is distinct from the two already known Cyclooxygenase enzymes Cox-1 & Cox-2. It is now believed that this selective inhibition of the enzyme Cox-3 in the brain & spinal Cord explains the effectiveness of paracetamol in relieving pain & reducing fever without having unwanted gastrointestinal side effects.
    Ref.: Chandrasekharan, N.V. et. al., 2002, Cox-3, a Cyclooxygenase-1 Variant inhibited by acetaminophen & other analgesic/antipyretic drugs: coloning, structure, and expression, Proc. Natt. Acad. Sci., USA, 99, 13926-13931.
  • In laboratory animals & humans, relative potency has been established for NSAID: Meclofenamic acid > indomethacin > naproxen > phenyl butazone > aspirin and similar pattern occurs in domestic animals.
    Ref.: Lee. P., and Higgins, A.J. 1985, clinical pharmacology & therapeutic uses of NSAID in Horse, Equine Vet. J. 17;83-96
    Ref.: Vane, J.R. & Batting R. 1987, inflammation & the mechanism of action of anti inflammatory drugs FASEB J.I: 89-96.
Meloxi DOWNLOAD BROCHURE
Dummy Matter.
Meloxi
Nimulite Plus DOWNLOAD BROCHURE
Fast, safe and powerful anti-inflammatory, antipyretic and analgesic

Composition:
Each bolus contains:
Nimesulide BP 400 mg
Paracetamol IP 1500 mg

Nimesulide is a newer nonsteroidal anti-inflammatory drug (NSAID) with selective cyclo-oxygenase-2 (COX-2) enzyme inhibiting property.
Paracetamol is a analgesic and antipyretic in action with the property of inhibiting COX-3 Cyclooxygenase enzyme.

Salient features
Nimesulide
  • Nimesulide has potent analgesic, anti pyretic and anti-inflammatory activity on oral administration.
  • Nimesulide does not alter the constitutive COX enzyme (COX-1) which is essential for physiological function of the body.
  • Nimesulide shows significantly faster reduction in fever.

Paracetamol
  • Preferential Cox-2 and Cox-3 inhibitor
  • Excellent antipyretic
  • Potent analgesic
  • Safe with no residual effect
  • Non Carcinogenic
  • More effective against inflammatory conditions in the C.N.S.


Nimulite Plus
Nimesulide
Mode of action
The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine. Clinical evidence is available to support a particularly good profile in terms of gastrointestinal tolerability.

Pharmacokinetics
Nimesulide is rapidly absorbed following oral administration and peak plasma levels are obtained within 1-3 hours. The drug is extensively bound (99%) to plasma protein and has an elimination half-life of 2-5 hours. Nimesulide is mainly eliminated by hepatic biotransformation. Excretion of nimesulide metabolites in the urine and feces account for about 80% and 20% of the administered dose, respectively.

Paracetamol
Mode of action
Paracetamol or acetaminophen is a analgesic (pain reliever) and antipyretic (fever reducer) in action Paracetamol is derived from coal tar, and is therefore part of the class of drugs known as “aniline analgesics”. Its main mechanism of action is the inhibition of cyclooxygenase (COX), an enzyme responsible for the production of prostaglandins. The production of prostaglandins is part of the body's inflammatory response to injury, and inhibition of prostaglandin production around the body by blocking the cyclooxygenase enzymes known as COX-1 and COX-2 has long been known to be the mechanism of action of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. However, their action in blocking COX-1 is known to be responsible for also causing the unwanted gastrointestinal side effects associated with these drugs. Paracetamol has no significant action on COX-1 and COX-2, which left its mode of action a mystery but did explain its lack of anti-inflammatory action and also, more importantly, its freedom from gastrointestinal side effects typical of NSAIDs. Now, recent research has shown the presence of a new, previously unknown cyclooxygenase enzyme COX-3, found in the brain and spinal cord, which is selectively inhibited by paracetamol, and is distinct from the two already known cyclooxygenase enzymes COX-1 and COX-2. It is now believed that this selective inhibition of the enzyme COX-3 in the brain and spinal cord explains the effectiveness of paracetamol in relieving pain and reducing fever without having unwanted gastrointestinal side effects.

Pharmacokinetics
Paracetamol is readily absorbed with peak plasma concentration reaching in 10-60 minutes. It is distributed into most body tissue. It crosses the placenta and is present in milk. Plasma protein binding is negligible at usual therapeutic concentrations. The elimination half life is 1-3 hrs. Paracetamol is metabolised predominantly in the liver and excreted in the urine. Less than 5 % is excreted as unchanged paracetamol.

Indications
  • Pyrexia of unknown origin or pain & fever associated with infections.
  • Inflammatory conditions following reproductive disorders like metritis, prolapse & mastitis.
  • Acute & Chronic inflammatory conditions like osteoarthritis, rheumatoid arthritis, myositis, lameness, pharyngitis, otitis, & rhinitis.
  • Gastrointestinal colic and renal colic
  • Mild & moderate post-operative care
  • Hip dysplasia in dog.

Contraindication
  • In cases of known hypersensitivity to either of the drug.
  • Hepatic, renal or cardiac diseases.
  • In patients with gastrointestinal bleeding, active gastric or duodenal ulcers, or a history of recurrent ulceration.
  • Paracetamol is extremely toxic to cats, and should not be given to them under any circumstances. Cats lack the necessary glucuronyl transferase enzymes to safely break paracetamol down, and minute portions of paracetamol may prove fatal.
  • Not recommended in advance stage of pregnancy.

Dosage
Large animals : 2 boli twice daily
Small animal : 1 bolus twice daily

Presentation
4 boli strip.