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Anthelmintics
 
  • Alzol
  • Flunil Plus
  • Indocard
  • Oxzol
  • Parid
  • Parid Pour-On
Alzol Vet. DOWNLOAD BROCHURE
Broad spectrum anthelmintic

Composition:
Powder : Albendazole I.P. 5 % w / w
Suspension : Albendazole I.P. 2.5 % w / v Bolus
Albendazole IP 1.5 g & 3.0 g

A benzimidazole anthelmintic, insoluble in water and soluble in alcohol.

Salient features
  • Alzol is highly effective against round worms, lung worms, tape worms and liver flukes.
  • It is effective against immature and mature worms.
  • It is safe in young, old and debilitated animals and poultry.

Mechanism of action
Parasitic helminths must maintain an appropriate feeding site, and nematodes and trematodes must actively ingest and move food through their digestive tract to maintain an appropriate energy state, this requires proper neuromuscular co-ordination. The pharmacological basis of the treatment of helminthes generally involves interference with one or more of these functions that is destruction of energy process and subsequent starvation of the parasite or neuromuscular co-ordination leading to paralysis of the parasite and its subsequent expulsion. Benzimidazole (albendazole) acts in the same manner.

Alzol Vet.
  • Inhibition of enzyme in the glycolytic pathway.
  • Inhibiting the breakdown of excitatory neurotransmitters by mimicking the action of the excitatory transmitter.

Pharmacokinetics
The drug is absorbed orally, approximately 47% of an oral dose was recovered (as metabolites) in the urine over a 9 day period. The active metabolites, albendazole sulphoxide and albendazole sulfone reached peak plasma concentrations 20 hours after dosing. Its anthelmintic activity is primarily due to the sulfoxide metabolite.

Contraindication / precautions
Not recommended in cattle,sheep during the first 45 days of pregnancy. Albendazole has been associated with teratogenic and embryotoxic effects in rats, rabbits and sheep when given early in pregnancy.

Indications
  • Major gastrointestinal nematodes of ruminants.
  • Whip worms of ruminants, pig, dog and cat.
  • Lung worms of horse, ruminants, pig, dog and cat.
  • Bladder worms of dog and cat.
  • Ostertagia larvae in ruminants.
  • Tape worms in dog, cat and ruminants.
  • Flukes in ruminants, dog, cat and horses.
Dosage
Powder :
Cattle 15 g. per 100 kg. b.wt.
Horse,Camel & pig 10 g. per 100 kg. b.wt.
Sheep & Goat 2 g. per 20 kg. b.wt.
Dog & Cat 2 g. per 10 kg. b.w.

Suspension :
Horse,Camel & pig 6 ml per 30 kg. b.wt.
Cattle 30 ml per100 kg. b.wt.
Sheep & Goat 6 ml per 30 kg. b.wt.
Dog and Cat 1 ml per 2.5 kg. b.wt

Bolus:
Horse,Camel & pig 5.0 mg per kg. b.w. or 1.5 g. bolus for 300 kg. b.wt.
Cattle 7.5 mg.per kg. b.wt. or 3.0 g. bolus for 400 kg.b.wt.

Presentation:
Powder 30 g. and 300 g.
Suspension 30 ml
Bolus 3.0 g. strip of 1 bolus
1.5 g. strip of 2 boli
Flunil Plus DOWNLOAD BROCHURE
Most effective synergistic combination of Levamisole & Oxyclozanide, as wormicide and flukicide. with proven performance against gastrointestinal, pulmonary nematodes & liver fluke infestation.

Each Bolus Contains:
Levamisole Hcl I.P. 2 g
Oxyclozanide I.P. Vet 4 g

Salient features
  • Levamisole has been shown to be an effective alternative treatment in cases where anthelmintic resistance has developed to other chemically unrelated anthelmintic products.
  • Levamisole has also garnered much interest as an immunostimulant.
  • Levamisole is very rapidly absorbed & peak plasma concentration attained within 1-3 hrs. after oral dosing.
  • Levamisole is rapidly distributed to all tissues and elimination from plasma & tissues is also very rapid, in urine 50% & faeces 30% within 24 hrs.
  • Oxyclozanide is slowly absorbed after oral administration with peak plasma levels 24 hrs after dosing. Excretion is predominantly faecal.
  • Oxyclozanide is not mutagenic or structurally related to a known carcinogenic.
  • Oxyclozanide also removes tape worm (moniezia spp.) in sheep.
  • Elimination half life of Oxyclozanide is about 24 hrs. During 5 days after administration 84% of the dose was excreted in faeces, 7.5% in urine & less than 0.07% in milk.

Mode of action :

Levamisole is an imidazothiazole that acts by interfering with parasite nerve transmission causing muscular paralysis. It is effective against adult & immature gastrointestinal round worm and lung worm infestation. Levamisole dose in cattle is 7.5 mg / kg b.wt. and in sheep- 7.5 mg per kg b.wt.


Flunil Plus
Pharmacokinetics - Levamisole is very rapidly absorbed and peak plasma concentration is achieved with in 1-3 hours after oral dosing. It is reportedly distributed throughout the body. Levamisole is primarily metabolized with less than 6% excreted unchanged in the urine. Plasma elimination half-lives have been determined for several veterinary species: Cattle 4-6 hours; Dogs 1.8-4 hours; and Swine 3.5-6.8 hours. Metabolites are excreted in both the urine (primarily) and faeces.

Oxyclozanide is a salicylanilide which act at more than one site to decrease levels of ATP leading to metabolic malfunction & death of the parasite. It is an excellent oral fasciolicide & is one of the most effective formulation for the treatment & control of Fascioliasis and Amphistomosis in Cattle, Buffaloe, Sheep, Goat & other Livestock. The dose of oxyclozanide in cattle is 10-15 mg / kg b.wt. and in sheep -15 mg / kg b.wt.

Pharmacokinetics
Oxyclozanide is slowly absorbed after oral administration with peak plasma level 24 hours after dosing. excretion is predominantly faecal.

Indications:

  • For the treatment & control of both gastrointestinal & pulmonary nematode infections & adult liver fluke infections. The product also removes most mature Fasciola spp. (flukes) present in the bile ducts of the liver.
  • The product is effective against the following worms in particular.
    In the abomasum:  Haemonchus, Ostertagia and Trichostrongylus spp.
    In the intestines:  Trichostrongylus, Cooperia, Nematodirus, Oesphagostomum, Chabertia and Bunostomum spp.
    In the lungs:  Dictyocaulus spp. 
  • For the effective treatment of acute and chronic fascioliasis in cattle, buffaloes, sheep and goats.
  • At recommended doses remove practically all flukes from bile ducts irrespective of their stage of maturity.
  • Effective against amphistomiasis (paramphistome).
  • Removes tapeworm segments of Moniezia spp.

Contraindications / precautions
  • Do not use in animals with known hypersensitivity to the active ingredients.
  • Cattle should not be treated with in a period of 14 days before or after treatment with organophosphorus compounds. (Organophosphorus compounds are chemical compounds containing carbon-phosphorus bonds, primarily used in pest control)
  • Use the product in recommended doses.

Use during pregnancy
  • It may be given to young and pregnant animals but care should be taken while treating the animals in advance pregnancy, under stress from adverse weather conditions, poor nutrition etc.

Interactions with other medicines
Other nicotine-like compounds (e.g. pyrental, morantel, diethylcarbamazine), or cholinesterase –inhibitor drugs (e.g. organophosphates, neostigmine) may enhance the toxic level of levamisol. Fatalities have been reported after concomitant levamisole and chloramphenicol administration, avoid using these drugs together.

Adverse effects
  • Over dosing may cause head shaking, salivation and slight muscle tremors. These effects are transient.
  • Animal may show slight softening of faeces with increase frequency of defecation and transient inappetance. These effects are occasionally enhanced in animals with severe liver damage and / or dehydration at the time of dosing.
  • In lung worm infestation, coughing may persist for a considerable time following successful treatment with the drug. This is due to tissue damage caused by the parasites.

Dosage
Target species - cattle and sheep
Large animal - 1 bolus
Small animal - ½ bolus
Single dose, orally to be repeated after 3-4 months or as required
(The body weight of animals should be assessed as accurately as possible before calculating the dosage.)

Presentation

1 bolus strip
Indocard DOWNLOAD BROCHURE
Synthetic pyrethroid for prevention and control of ticks, mites, lice and fleas.

Composition:
Each ml contains
Cypermethrin – High CIS 100 mg

Salient features
  • Greater potency and residual effect
  • Prolonged activity
  • Low mammalian toxicity and irritability
  • High margin of safety
  • Repellent activity against fleas, ticks and mosquitoes.

Cypermethrin is a pyrethroid insecticide. It acts as a fast-acting neurotoxin in insects.

Mode of action
Cypermethrin works by quickly affecting the insect’s central nervous system hence kills insects that eat or come into contact with it.

Indication
Prevention and control of ticks, mites, lice, and fleas.

Indocard

Precaution

  • Avoid direct contact with eyes and skin.
  • Prevent licking by the animals.

Withdrawal time
No withdrawal time for milk. Three days pre-slaughter interval for meat.

Cypermethrin in the environment
The typical half-life of cypermethrin in the soil is 30 days, although it can range from two to eight weeks. Soil microbes rapidly break down cypermethrin. Cypermethrin has an extremely low potential to move in the soil. It is unlikely to contaminate groundwater because it binds tightly to soil particles. Cypermethrin is stable in sunlight.

Administration and Dosage
Body spray or dip 1-2 ml in 1 liter of water
Back line spray 5 ml in 1 liter of water
Animal housing 20 ml in 1 liter of water

For better results:
  • Indocard application be repeated after 10 days in heavily infected animals.
  • Indocard should be used as prophylaxis once in three months.
  • Indocard must be sprayed in animal housing before and after rainy Season.

Presentation

10 ml and 15 ml
Oxzol DOWNLOAD BROCHURE
Latest broad spectrum anthelmintic

Formulation :
Bolus contains Oxfendazole I.P.(Vet) 2200 mg
Liquid contains Oxfendazole I.P.(Vet ) 2.265 % w/v

Oxfendazole is a benzimidazole anthelmintic, effective against most of the parasites of livestock & poultry.

Salient features
  • Oxzol is economical and effective against major endo-parasites in domestic animals.
  • Oxzol is ovicidal, larvicidal and wormicidal in action.
  • Oxzol is well tolerated by the domestic and wild animals in general and free of side effects at therapeutic doses.
  • Oxzol is safe in young, sick and debilitated animals.
  • Oxzol is safe in pregnancy at therapeutic doses.
  • Safety margin 10 times of therapeutic doses.
  • Slow absorption from gastrointestinal tract prolongs its action.

Mode of action
The drug acts on parasites by interfering with their energy – generating metabolism. Oxfendazole is inhibitor of fumerate reductase. Blockage of the fumerate reductase step inhibits generation of mitochondrial energy in the form of adenosine triphosphate (ATP). In the absence of usable energy, the parasite dies.

Oxzol

Pharmacokinetics
The peak plasma level occurs in 6-30 hours after dosing with oxfendazole. The plasma levels are increased and anthelmintic activity is enhanced when the drug is retained in the rumen rather than passed directly into the abomasums via closure of oesophageal groove. Oxfendazole is excreted primarily through urine of monogastric animals and through faeces (65%) of ruminants

Anthelmintic spectrum
Horses -
The drug is effective against adult form of large strongyles, small strongyles, mature Oxyuris equi, small pin worm (Probstmayria vivipara) and Trichostrongylus axeif of horses. Ascarids (Parascaris equorum) and immature Oxyuris.

Cattle and sheep
The drug is effective for lung worm infection caused by Dictyocaulus All the major gastrointestinal parasites of ruminants (Haemonchus, Ostertagia, Trchostrongylus, Marshallagia, Cooperia, Nematodirus, Bunostomum, Chabertia, Oesophagostomum, Strongyloides). The adult form of these parasites is most effectively expelled but immature stages are also eliminated. Oxfendazole is effective against whipworms.

Swine
The drug is effective against swine ascarids (sexually mature adult forms), stomach worms (Hyostrongylus), nodular worms (Oesophagostomum) and Strongyloides. Swine lung worms (Metastrongylus)

Poultry
Ascaridia galli, Capillaria, Cecal worms (Heterakis gallinarum). Currently, there are no approved drugs for treatment of Capillaria, Tape or Cecal worms in poultry. As a result, the drug oxfendazole is used extra-label in drinking water when prescribed and monitored by a licensed veterinarian.

Ovicidal activity
Studies on the culturability of parasite eggs in feces following treatment of animals with oxfendazole suggest a strong ovicidal property.The drug has been found to be ovicidal for eggs of ruminants Trichostrongylids, swine stomach worms (Hyostrogylus) chicken ascarids and canine and human hookworms and whipworms.

Safety and toxicity
Oxfendazole is well tolerated by domestic and wild animals in general. Oxfendazole is free of side effects at therapeutic doses even when administered to young, sick or debilitated animals. In ruminants and horses oxfendazole does not cause detectable toxic effect at a single administration of 10 times the recommended dose. Sheep tolerate 20 times the therapeutic dose.

Contraindications
Oxfendazole should not be administered simultaneously with bromsalan flukicides (oxyclozanide). This combination has produced some abortions in cattle and deaths in sheep.

Dosage and administration
The drug is administered orally.
Horse 10 mg per kg b.wt. or 1 ml per 2.25 kg b.wt.
Cattle 4.5 mg per kg b.wt or 1 ml per 4.50 kg b.wt.
Sheep 5 mg per kg b.wt or 1 ml per 4.50 kg b.wt.
Swine 3 mg per kg b.wt. or 1 ml per 5.50 kg b.wt.
or
4.5 mg per kg b.wt for control of Hyostrongylus and Oesophagostomum spp.
Dog 11.3 mg per kg. b.wt. or 1 ml per 2.00 kg b.wt.
For 3 consequent days.
Poultry 10 mg per kg b.wt. or 1 ml per 2.25 kg b.wt.

Presentation
Bolus 1 bolus strip
Liquid 15 ml, 100 ml and 500 ml.

Oxzol v/s Fenbendazole
Oxfendazole is a sulphoxide identical to the sulphoxide metabolite of fenbendazole, both are known to be anthelmintically active and metabolically interconvertible. Much of fenbendazole’s anthelmintic activity is attributed to oxfendazole, the latter being more potent.

Oxzol v/s Piperazine (poultry)
Oxfendazole:The drug acts on parasites by interfering with their energy – generating metabolism. Oxfendazole is inhibitor of fumerate reductase. Blockage of the fumerate reductase step inhibits generation of mitochondrial energy in the form of adenosine triphosphate (ATP).In the absence of usable energy, the parasite dies.
Piperazine: It blocks transmission by hyperpolarizing nerve membranes at the neuromuscular junction and induces flaccid paralysis. Mature worms are more susceptible to the action of peperazine than the younger stages. In extremely heavy ascarid infections, treatment with piperazine may immobilize veritable masses of worms and cause an intestinal impaction.
Oxfendazole: It is also effective against cecal worm Heterakis gallinarum.
Piperazine: The cecal worm (Heterakis gallinarum) apparently is not susceptible to piperazine.

References:
Oxfendazole single dose @ 4.5 mg/kg body weight is highly efficacious against strongyles in buffalo calves.
Neelesh Sharma1, Vijay Pandey2, S.K. Gupta and S.R. Upadhyay
Division of Veterinary Clinical Medicine & Jurisprudence, Faculty of Veterinary Science and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology of Jammu.


Efficacy of oxfendazole against naturally acquired gastrointestinal nematode infestations in buffaloes in Egypt.
A 100% reduction in faecal egg counts was obtained at the 4·5 mg/kg level.
S. A. Michael1, A. H. El Refaii1 and A. J. Higgins2
The Department of Parasitology, Animal Health Research Institute, Dokki, Cairo, Arab Republic of Egypt.
The Wellcome Foundation Ltd., Berkhamsted, Hertfordshire, UK


Oxfendazole effective in removing all developmental stages of naturally acquired Dictyocaulus viviparus from 15-week-old calves (2.5 mg/kg) and D.filaria from sheep (5.0 mg / kg). (lung worms)
Chalmers K. New Zealand Veterinary Journal, Volume 27, Numbers 1-2,1 January 1979, pp. 8-13(6)

Efficacy of oxfendazol agaist natural infestation of nematodes and cestodes in sheep in Egypt.
A 100 per cent clearance was recorded for all parasites with the exception of T ovis which were markedly reduced in number.
SA Michael, AH Refaii, WH Mansour, MK Selim, and AJ Higgins
The Veterinary Record, Vol 104, Issue 15, 338-340
Copyright © 1979 by British Veterinary Association


Oxfendazole was 100% effective against third, fourth, early fifth, and adult stages of the Haemonchus contortus worms at dosage level 5 mg/kg and 10mg /kg body weight.
Kistner TP, Wyse D Aust Vet J. 1978 Oct;54(10):469-70.

Anthelmintic activity of oxfendazole in pigs.
A dose rate of 4.5 mg oxfendazole per kg body-weight give practical control of Hyostrongylus and Oesophagostomum species in pigs.
PA Kingsbury, DT Rowlands, and JF Reid The Veterinary Record, Vol 108, Issue 1, 10-11 Copyright © 1981 by British Veterinary Association

Oxfendazole provides, for the first time, a practical, effective, inexpensive, and single-dose therapy for porcine cysticercosis.
Armando E. Gonzales, Hector H. Garcia, Robert H. Gilman, Cesar M. Gavidia, Victor C. W. Tsang, Teresa Bernal, Nestor Falcon, Martha Romero AND Maria T. Lopez-Urbina
Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia Am. J. Trop. Med. Hyg., 54(4), 1996, pp. 391-394


Br Vet J. 1989 Sep-Oct;145(5):458-61.
Anticestodal action of oxfendazole on Raillietina tetragona in experimentally infected chickens.
Nurelhuda IE, Elowni EE, Hassan T.
Abstract
Oxfendazole was tested against Raillietina tetragona in experimentally infected chickens using single oral doses of 20, 10, 7.5, 5, and 2.5 mg/kg body weight. The minimal dose of the drug which produced 100% efficacy against immature worms was 10 mg/kg whereas the same effect on the mature parasite was obtained with 7.5 mg/kg. Doses lower than these significantly reduce worm burdens. The compound appears to be safe for chickens and a dose of 20 mg/kg (twice the recommended dose) produced no untoward clinical reactions.
PMID: 2790437 [PubMed - indexed for MEDLINE]

Parasite. 2000 Sep;7(3):221-6.
Efficacy of oxfendazole for the treatment of giardiosis in dogs. Experiments in dog breeding kennels.
Villeneuve V, Beugnet F, Bourdoiseau G.
Abstract
Giardiosis is one of the most frequent parasites of dogs and cats. Since several years, the treatment is based on the use of metronidazole. A coproscopic study in four dog kennels was conducted to demonstrate, at a significant level, the efficacy of oxfendazole (Dolthène, Merial). At the posology of 11.3 mg/kg each day during three days (D1, D2 and D3), no dogs eliminated Giardia cysts and all dogs are clinically cured. The importance of hygienic measures is underlined. In kennels 1 and 2 where hygienic conditions were poor, dogs reexcreted cysts again after treatment. In kennels where the boxes were disinfected, no dogs, treated with 22.6 or 11.3 mg/kg, reexcreted Giardia cysts.
PMID: 11031759 [PubMed - indexed for MEDLINE]
Parid DOWNLOAD BROCHURE
The best Ectendoparaciticidal product

Formulation
Each ml contains :
Ivermectin 10 mg.

Salient features
  • Wide safety margin.
  • Safe in pregnant animals.
  • Very high antiparasitic activity even in small doses.
  • Stress free treatment.
  • Persistent activity against both mature and immature stages of nematodes.

There are several classes of anthelmintics, eg, benzimidazoles and probenzimidazoles, salicylanilides and substituted phenols, imidazothiazoles, organophosphates, and macrocyclic lactones. Because of their broad spectrum, high efficacy against all parasitic stages, and their persistent activity, macrocyclic lactones now dominate the treatment and control of nematodes Ivermectin belongs to group of macrocyclic lactones. (ivermectin, abamectin, doramectin, moxidectin, milbemycin oxime, eprinomectin, selamectin).

Macrocyclic lactones are lipophilic, an important characteristic of this class of anthelmintics. Regardless of their route of administration, macrocyclic lactones are distributed throughout the body and concentrate in adipose tissue. While the magnitude of lipophilicity differs among chemical types,

Parid
the limited vascularization and slow turnover rate of body fat and the slow rate of release or exchange of drug from these lipid reserves prolongs the residence of drug in the peripheral plasma.

Mechanism of action:
Ivermectin enhances the release of gamma amino butyric acid (GABA) at presynaptic neurons. (Neurons communicate with one another via synapses. Synapses are specialized junctions between two cells in close apposition to one another) GABA acts as an inhibitory neurotransmitter and blocks the post synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA, ivermectin causes paralysis of the parasite and eventual death. As liver flukes and tapeworms do not use GABA as a peripheral nerve transmitter, ivermectin is ineffective against these parasites.

The macrocyclic lactones paralyze the pharynx, the body wall, and the uterine muscles of nematodes. Paralysis (flaccid) of body wall muscle may be critical for rapid expulsion, even though paralysis of pharyngeal muscle is more sensitive. As the macrocyclic lactone concentration decreases, motility may be regained, but paralysis of the pharynx and resultant inhibition of feeding may endure longer than body muscle paralysis and contribute to worm deaths. In filarial nematodes living in the tissues, females move very little and nutrients are absorbed through the cuticle. A major effect of macrocyclic lactones on adult worms of these species is probably paralysis of uterine muscles, resulting in disruption of reproduction. None of the macrocyclic lactones are active against cestodes or trematodes, presumably because these parasites do not have a receptor at a glutamate-gated chloride channel.

Pharmacokinetics – The peak plasma concentration being obtained 4 hours of injection. The bioavailability of ivermectin subcutaneous route is more than 95%. It has a plasma elimination half-life of about 12 hours.

Ivermectin is well distributed to most tissues, but does not readily penetrate into the CSF (cerebrospinal fluid), thereby minimizing its toxicity. Collie-Breed dogs apparently allow more ivermectin into the CNS than other breeds/ species.

Ivermectin has a long terminal half-life in most species. The biological life half life of ivermectin in plasma is similar in cattle and sheep but because of a larger volume of distribution, plasma clearance is more rapid in sheep. It is metabolized in the liver via oxidative pathways and is primarily excreted in the feces. Less than 2% of the drug (as parent compound or metabolites) is excreted in the urine and less than 5% in milk.

Toxicity
In cattle, toxic effects generally do not appear until dosages of 30X those recommend are injected. At 8mg/kg, cattle showed symptoms of ataxia, listless and occasionally death. When used to treat Hypoderma bovis larva (Cattle grubs) in cattle, ivermectin can induce serious adverse effects by killing the larva when they are in vital areas. Larva killed in the vertebral canal can cause paralysis and staggering. Larva killed around the gullet( throat ) can induce salivation and bloat. Theses effects can be avoided by treating for grubs immediately after the Heal fly (Warble fly) season or after the stages of grub development where these areas would be affected. Cattle may also experience discomfort or transient swelling at the injection site. Using a maximum of 10 ml at any one injection site can help minimize these effects.

In dogs, symptoms of acute toxicity rarely occur at single dosages of 2 mg/kg (2000 micrograms/kg) or less. At 2.5 mg/kg mydriasis (mydriasis is an excessive dilation of the pupil due to disease, trauma, or the use of drugs ) occurs, and at 5 mg/kg tremors occur. At doses of 10 mg/kg, severe tremors and ataxia are seen. Dogs may exhibit a shock-like reaction when ivermectin is used as a microfilaricide (canine heart worm ), presumably due to a reaction associated with the dying microfilaria.

Warnings / Precautions
  • Ivermectin is not recommended for use in puppies less than weeks old. Ivermectin should not be used Collies or Collie-mix breeds at the doses specified for treating microfilaria or other parasites unless alternative therapies are unavailable. After receiving heartworm prophylaxis doses, observed Collie-breeds for at least 8 hours after administration.
  • The injectable products for use in cattle, sheep and camel should be given subcutaneously only; do not give IM or IV. Use with care in dog as severe adverse reactions may occur.
  • Ivermectin is considered to be safe to use during pregnancy. Reproductive studies performed in dogs, horses, cattle and sheep have not demonstrated adverse effects to refuses. Reproductive performance in male animals is also apparently unaltered.
  • Dogs who receive an overdosage of ivermectin or develop signs of acute toxicity (CNS effects, GI, cardiovascular) should receive supportive and symptomatic therapy.
  • Because milk withdrawal times have not been established, the drug is not approved for use in lactating dairy animals or females of breeding age.

Indications
In cattle & swine, ivermectin is approved for use in the control of: gastrointestinal roundworms (adults and 4th stage larva), lungworms (adult and 4th stage larva), cattle grubs (parasitic stages), sucking lice, eye worms (Thelazia) and mites (scabies).
In camel, it is a approved for use in the control of gastrointestinal nematodes, scabies and filariasis
In sheep gastrointestinal roundworms (adults and 4th stage larva), lungworms (adults and 4th stage larva), nasal bots and mange mites (sheep scab).

Dosage
Ivermectin (Parid) should be given only by subcutaneous injection at the recommend dosage level of 200 μg (0.2 mg / kg body weight) ivermectin per kg body weight under the loose skin in front of, or behind, the shoulder. in bovine, camelide and in neck of ovine, swine and caprine using aseptic techniques and 17 gauge x ½ inch needle.
In canines 200 mcg/kg body weight by subcutaneous route.

Presentation
1ml , 10 ml & 30 ml. vial

Caution
Food, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription of a licensed veterinarian.
Parid Pour–On DOWNLOAD BROCHURE
For Cattle
The only FDA approved tropical pour-on solution (Ivermectin)


Formulation
Contains Ivermectin 5mg/ml

Salient features
  • It is a ready-to-use weatherproof, transparent solution.
  • It is different from those of other anti parasite agent.
  • It provides wide margin of safety with minimal stress
  • It is well tolerated by breeding animals without effecting breeding performance.
  • It stimulates the release of GABA (gamma amino butyric acid) from nerve endings – thereby paralyzing and killing the parasites.
  • Parid pour- on protect cattle from re-infection upto 35 days.
  • Ivermectin Pour-on is the pioneer in broad-spectrum parasite control in a pour-on formulation.
  • Parid Pour on delivers internal & external parasite control in one convenient low – volume application.
  • Parid Pour-on controls horn flies (Haematobie irritans) for up to 28 days after dosing

Mechanism of action (detail given in injection parid literature).
Its action is unique, involves a chemical that serves as a signal from one nerve cell to another, or from a nerve cell to a muscle cell. This chemical, a neurotransmitter, is called gamma-aminobytric acid or GABA. In round worms, Ivermectin stimulates the release of GABA from nerve

Parid Pour-On
endings & enhances binding of GABA to special receptors at nerve junctions, thus interrupting nerve impulses – thereby paralyzing & killing the parasite. The enhancement of the GABA effect in arthropods such as mites, lice & horn flies resembles that in round worms. Ivermectin has no measurable effect against flukes or tapeworm, presumably because they do not have GABA as a impulse transmitter.

Indications
Mature & immature internal & external parasitic infestation including Horn Flies (Haematobia irritans)
Round worms (including Brown Stomach Worm) i.e. Ostertagia ostertagi, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punetata, C. surnabada, Strongyloides papillosus, O. radiatum, Lungworms (Dictyocaulus viviparous) Grubs, suckling lice, Biting lice & Mange mites (Chorioptic & sarcoptic). Spectrum of Parid Pour-on Endectocide

Indications
Company Vetsfarma Limited
Product Parid Pour-on
Active Ingredient Ivermectin 5mg/ml
Effective Control of Gastrointestinal Roundworms   √
Control of these costly external parasities: Horn Flies – Up to 28 days !   √
Biting & Sucking Lice   √
Grubs   √
Mange Mites   √
FDA Approved Generic Ivermectin   √

Caution
  • Use only in well ventilated areas
  • Do not use when hair or hide is wet.
  • Do not use when rain is expected to wet cattle within six hours.
  • Remove caked mud or manure before its application.
  • Not for human use and user should bear rubber gloves.
  • Do not allow cattle to enter lakes or ponds for at least six hours after application.
  • Store between 15°C & 30°C
  • The product is for application to skin surface only. Not to be used orally or parenterally.

Dosage and application
Parid pour-on: 1ml per 10kg live weight applied along the topline in a narrow strip from withers to the tailhead.

Presentation
50ml pour-on squeeze pack